A blood bank must be under the direction of a qualified person who has specific experience in the field of blood bank operations, hematology and immunohematology.

Any procedures involving the service of transfusing or injecting of blood or blood products into humans must be under the supervision of a medical director who has experience and/or training which is acceptable to the department. The medical director may also serve as the director of the blood bank if qualifications are suitable. Any time blood is being obtained from a human donor, a physician must be available who is licensed to practice medicine in the Commonwealth of Pennsylvania.