The regulations of this chapter apply to all CIRM grant awards issued on or after the effective date of these regulations. By accepting a CIRM grant award, the grantee agrees to comply with the provisions of these regulations. Any new or amended regulations adopted by the Independent Citizen's Oversight Committee (“ICOC”) will be applied to currently active grants on the start date of the next non-competitive renewal period after the effective date of the regulations. A currently active grant is a grant that is still in the Project Period or a grant for which CIRM funds are still being expended. New or amended regulations under this chapter adopted after the expiration of the Project Period of a grant and after all CIRM funds for the grant have been expended will apply on January 1 following the effective date of the new or amended regulation, unless specified otherwise in the regulation. Principal investigators, program directors and organizational officials with active CIRM grants will receive notification of revised grant terms and conditions or revised editions of the CIRM Grants Administration Policy as they are released. In addition, all revisions to these regulations will be posted on the CIRM website at www.cirm.ca.gov. Failure by a principal investigator or other person affiliated with the grantee to have notification of new or amended regulations, revised grant terms and conditions, or revised editions of the Grants Administration Policy, shall not excuse non-compliance as long as the CIRM has notified the grantee.